Area of Effect
Dan and I have already discussed this to some extent, the idea of instant perfect defenses working on high scale area of effect attacks doesn't make metaphysical sense. Charms like Heavenly Guardian of Defense have an instant duration and can't perfectly parry a simple unaided flurry, but work on amazingly powerful effects like The Soul Breaker Orb or Total Annihilation. If you intend to perfectly dodge a high powered area of effect attack it would be prudent to combo that perfect defense with a charm that removes you from the area.